Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations
نویسندگان
چکیده
منابع مشابه
Protein interactions, post-translational modifications and topologies in human cells.
The unique and remarkable physicochemical properties of protein surface topologies give rise to highly specific biomolecular interactions, which form the framework through which living systems are able to carry out their vast array of functions. Technological limitations undermine efforts to probe protein structures and interactions within unperturbed living systems on a large scale. Rapid chem...
متن کاملPost-translational modifications of protein biopharmaceuticals.
The majority of therapeutic proteins display one or more post-translational modifications (PTMs). These modifications normally influence the biochemical and therapeutic properties of such proteins. Choosing an expression system capable of generating an appropriate product PTM profile remains one of the most crucial decisions a drug developer must make. This review considers the PTMs most often ...
متن کاملPhosphoinositide 3-kinase Signalling Enzymes by Post-translational Modifications, Protein Interactions and Absolute Protein Expression Levels
Phosphoinositide 3-kinases (PI3Ks) are signal transduction proteins that regulate a wide range of cellular processes. A key subset of PI3Ks are the so-called class IA enzymes consisting of a p85 regulatory and p110 catalytic subunit. While the biological activities of PI3Ks have been investigated in detail, the biochemical mechanism of their regulation is underexplored. We therefore strived to ...
متن کاملDual Coordination of Post Translational Modifications in Human Protein Networks
Post-translational modifications (PTMs) regulate protein activity, stability and interaction profiles and are critical for cellular functioning. Further regulation is gained through PTM interplay whereby modifications modulate the occurrence of other PTMs or act in combination. Integration of global acetylation, ubiquitination and tyrosine or serine/threonine phosphorylation datasets with prote...
متن کاملEvolution and functional cross‐talk of protein post‐translational modifications
Protein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01808-6